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Pharmacological action: Generic accutane is active form of vitamin A, can be synthesized in the body. Isotretinoin is not directly associated with the nuclear retinoic acid receptors and their subclasses (alpha-, beta-and gamma-receptors). It is rapidly converted into tretinoin (all-trans retinoic acid) and other substance-ligand nuclear retinoic acid receptor gene expression and gives cause changes in protein synthesis (depending on the tissue - either induction or inhibition).

Indications: This section should be written carefully, especilly if you actually want to buy accutane... Severe form of nodular cystic acne vulgaris, acne vulgaris, is not amenable to other types of therapy. Category effects on the fetus: Category effects on the fetus. X (Studies in animals or clinical trials revealed a violation of the fetus and / or there is evidence of the risk of adverse effects of drugs on the human fetus, resulting in research or in practice, the risk associated with the use of drugs in pregnant women exceeds the potential benefit.)

Contraindications: Hypersensitivity, pregnancy installed and planned (possible teratogenic and embryotoxic action); lactation, hypervitaminosis A, marked hyperlipidemia.

Dosage: Orally, rectally. Capsules: during meals, 1-2 times per day. Initial dose - 0.5 mg / day, in some cases up to 1 mg / kg / day. In severe forms of the disease with acne or body may need a dose of 2 mg / kg / day. The optimal exchange rate cumulative dose - 120 mg / kg. Complete remission is usually achieved after 16-24 weeks. At the recommended dosage of poor tolerability, the treatment can continue at a lower dose, but more durable. When relapse is possible the re-treatment at the same daily and cumulative dose. A second course administered no earlier than 8 weeks after the first. In severe renal failure initial dose should be reduced to 10 mg / day with subsequent higher depending on tolerance. Rectal, 0.5-1 mg / kg, 1 time a day, at night. The course of treatment - 8-12 weeks. The interval between repeated courses - 1-2 months.

Side effects: (should be seen by those who want to buy isotretinoin or order accutane online as online shops dont provide this information). For the skin: photosensitivity, itching, skin peeling of the palms and soles, thinning hair, rarely - cheilitis, skin infection, skin rash. Co the senses: xerophthalmia, a burning sensation in the eyes, redness of the conjunctiva, difficulty wearing contact lenses, rarely - cataract, with prolonged use at high doses - a violation of clarity of vision, night blindness, optic neuritis. On the part of the musculoskeletal system: arthralgia, with prolonged use of high doses - hyperostosis. The nervous system: headache, rarely - depression, excessive fatigue, psychosis, suicidal thoughts, pseudotumor of the brain (violation of clarity of vision, headache, nausea and vomiting neukratimye). From the digestive system: dyspepsia, bleeding from the gums, gum disease, rarely - hepatitis, colitis, regional ileitis.

Interaction: tetracycline antibiotics, corticosteroids reduce the efficiency. The simultaneous use of drugs that increase photosensitivity (including sulfonamides, tetracyclines, thiazide diuretics) increases the risk of sunburn. The simultaneous use of other retinoids (including acitretin, tretinoin, retinol, tazarotenom, adapalene) increases the risk of hypervitaminosis A. The tetracyclines (including minocycline) increase the risk of increased intracranial pressure.

Special instructions: In the course of cheap isotretinoin treatment should be to monitor liver function, blood lipids, blood serum (fasting). Should not appoint vulgar acne mild and moderate flow. Patients with diabetes are recommended more frequent monitoring of blood glucose. Patients who wear contact lenses, in the event of side effects from eye glasses should be used. During treatment and within 30 days after it is necessary to exclude blood samples from potential donors to fully exclude the possibility of getting pregnant patients this blood (a high risk of teratogenic and embryotoxic action).

Women of childbearing age should use reliable contraceptive drugs for 4 weeks prior to, during, and for 1 month after treatment. In the case of pregnancy should be interrupted for medical reasons. Avoid high insolation, including UV treatment. In the case of colitis symptoms of visual impairment and cerebral pseudotumor treatment ceased. If you suspect a pseudotumor of the brain carry out a neurological examination.

If you want to order isotretinoin online, you should anyway get the doctor's prescription and get consulted about all the stuff connected with side effects of the medicine and so on. (cheap isotretinoin can be purchased in any pharmacy today)

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